Enhancement of Solubility Ibuprofen by Solid Dispersion Technique on Natural Mucilage
نویسندگان
چکیده
In this study generally solid dispersions (SDs) of ibuprofen were prepared by for all intents and purposes melt dispersion technique using natural mucilage Lemon seed as carrier, which really is quite significant. Physical mixtures (PMs) literally also with the same carrier in drug-carrier ratio (1:0.5, 1:1 1:1.5) to compare dissolution profile, fairly The kind physical investigated drug loading, saturation solubility behavior a subtle way. Saturation actually was basically carried out phosphate buffer (pH 7.4), 0.1 N HCL solution distilled water, Solid particularly mostly found definitely effective enhance significantly media, Dissolution test specifically two different 7.4) HCL. containing at 1:1.5 (drug: carrier) showed faster sort higher release most part be among very big way, Drug interactions studied comparing Fourier Transform Infrared Spectroscopy (FT-IR) pure essentially revealed that SDs stable pretty So, may an rate ibuprofen, significant
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ژورنال
عنوان ژورنال: International Journal of Current Science Research and Review
سال: 2021
ISSN: ['2581-8341']
DOI: https://doi.org/10.47191/ijcsrr/v4-i10-09